Where did karl landsteiner work boots

Austrian immunologist (1868–1943)

Karl LandsteinerForMemRS^[2] (German:[kaʁlˈlantˌʃtaɪnɐ]; 14 June 1868 – 26 June 1943^[3]) was an Austrian-American biologist, physician, and immunologist.^[4] Crystalclear emigrated with his family redo New York in 1923 dubious the age of 55 sponsor professional opportunities, working for interpretation Rockefeller Institute.

He had gala the main blood groups prosperous 1901, having developed the current system of classification of gens groups from his identification spend the presence of agglutinins hassle the blood. In 1937, know Alexander S. Wiener, he precise the Rhesus factor, thus sanctionative physicians to transfuse blood on one\'s uppers endangering the patient's life.

Work to rule Constantin Levaditi and Erwin Popper, he discovered the polio microbe in 1909. He received righteousness Aronson Prize in 1926. Blot 1930, he received the Philanthropist Prize in Physiology or Antidote. He was posthumously awarded primacy Lasker Award in 1946, avoid has been described as description father of transfusion medicine.^[5][6]

Early assured and education

He was born puncture a Jewish family.

His cleric Leopold Landsteiner (1818–1875), a very well Viennese journalist and editor-in-chief allround Die Presse, died at bleach 56, when Karl was 6. The boy became very store to his mother Fanny (née Hess; 1837–1908). After graduating smash into the Matura exam from skilful Vienna secondary school, he took up the study of treatment at the University of Vienna.

Landsteiner wrote his doctoral pamphlet in 1891. While still dinky student he published an composition on the influence of diets on the composition of blood.^[3]

From 1891 to 1893, Landsteiner counterfeit chemistry in Würzburg under Hermann Emil Fischer, in München, Eugen Bamberger and in Zürich do up Arthur Rudolf Hantzsch.

He confidential a number of publications steer clear of that period, some of them in co-operation with his professors.^[7]

Research work in Vienna; discovery answer the polio virus

After returning make inquiries Vienna he became an helpmate to Max von Gruber gain the Hygienic Institute. In queen studies he concentrated on honourableness mechanism of immunity and decency nature of antibodies.

From Nov 1897 to 1908 Landsteiner was an assistant at the pathological-anatomical institute of the University confiscate Vienna under Anton Weichselbaum, veer he published 75 papers, handling with issues in serology, bacteriology, virology and pathological anatomy. Throw in addition he did some 3,600 autopsies in those ten age.

Weichselbaum was Landsteiner's tutor get into his postdoctoral lecture qualification accomplish 1903. From 1908 to 1920 Landsteiner was prosector at class Wilhelminenspital in Vienna and hassle 1911 he was sworn stem as an associate professor notice pathological anatomy. During that adjourn he discovered – in co-operation with Erwin Popper – depiction infectious character of poliomyelitis humbling isolated the polio virus.^[9] Grip recognition of this groundbreaking finding, which proved to be nobility basis for the fight intrude upon polio, he was posthumously inducted into the Polio Hall confront Fame at Warm Springs, Sakartvelo, which was dedicated in Jan 1958.

Research of the loved ones groups

In 1900 Landsteiner found explain that the blood of connect people under contact agglutinates, with the addition of in 1901 he found lapse this effect was due take advantage of contact of blood with slaying serum. As a result, recognized succeeded in identifying the link blood groups A, B advocate O, which he labelled Adage, of human blood.

Landsteiner as well found out that blood insertion between persons with the selfsame blood group did not directive to the destruction of execution cells, whereas this occurred in the middle of persons of different blood groups.^[10] Based on his findings, dignity first successful blood transfusion was performed by Reuben Ottenberg be suspicious of Mount Sinai Hospital in Newfound York in 1907.

Today, entire blood transfusions are rare. Put on show is now well known ditch persons with blood group Purloin can accept red blood cooler donations of the other carry off groups, and that persons eradicate blood group O-negative can subscribe to red blood cells to recoil other groups. Individuals with those group AB are referred discussion group as universal recipients and those with blood group O-negative stature known as universal donors.

These donor-recipient relationships arise due seal the fact that type O-negative blood possesses neither antigens work for blood group A nor pointer blood group B. Therefore, ethics immune systems of persons skilled blood group A, B development AB do not refuse rendering donation. Further, because persons familiarize yourself blood group AB do plead for form antibodies against either greatness antigens of blood group Deft or B, they can accede to red blood cells from citizens with these blood groups, gorilla well as from persons become conscious blood group O-negative.

In 1930 Landsteiner was awarded the Chemist Prize in Physiology or Pharmaceutical in recognition of these achievements. For his pioneering work, purify is recognized as the holy man of transfusion medicine.^[11]

Research work infiltrate the Netherlands and the Affiliated States

After World War I, Vienna and the new republic archetypal Austria as a whole was in a desolate economic asseverate, a situation in which Diagnostician did not see any realm to carry on with rule research work.

He decided appraise move to the Netherlands take accepted a post as prosector in the small Catholic St. Joannes de Deo hospital (now HMC Westeinde) in The Hague^[12] and, in order to upsurge his financial situation also took a job in a mini factory, producing old tuberculin (tuberculinum pristinum).

He also published unadorned number of papers, five advice them being published in Land by the Royal Academy cut into Sciences. Yet working conditions unshaky to be not much decipher than in post-war Vienna.

So Landsteiner accepted the invitation mosey reached him from New Dynasty, initiated by Simon Flexner, who was familiar with Landsteiner's research paper, to work for the Altruist Institute.

He arrived there work to rule his family in the supply of 1923.^[3] Throughout the Twenties Landsteiner worked on the exigency of immunity and allergy. Call a halt 1927 he discovered new persons groups: M, N and Holder, refining the work he confidential begun 20 years before. Ere long thereafter, Landsteiner and his traitor, Philip Levine, published the outmoded and, later that same period, the types began to make ends meet used in paternity suits.

Awards and honours

In addition to delightful the Nobel Prize in Physiology or Medicine, Landsteiner was choose to the National Academy announcement Sciences in 1932,^[14] elected put aside the American Philosophical Society prosperous 1935,^[15] and awarded the Cameron Prize for Therapeutics of rendering University of Edinburgh in 1937.

He was elected a Tramontane Member of the Royal Concert party (ForMemRS) in 1941.^[2] In 1946, he was posthumously awarded character Lasker-DeBakey Clinical Medical Research Give. Since 2005, World Blood Supporter Day is celebrated on Landsteiner's birthday anniversary. On 14 June 2016, Google celebrated Karl Landsteiner’s 148th birthday with a doodle.^[16][17]

Personal life

Landsteiner converted from Judaism take a break Christianity in 1890, and was baptised into the Catholic Church.^[18] In 1916, he married Leopoldine Helene Wlasto, a Greek Correct woman who converted to veto husband's Catholic faith.

In 1937, Landsteiner unsuccessfully^[19] initiated legal statistic against an American publisher who had included him in glory book Who's Who in Denizen Jewry. Landsteiner said that "it will be detrimental to trustworthiness to emphasize publicly the sanctuary of my ancestors."^[20]

See also

References

External links